THE CHANGES WHICH ALTER RENAL OSMOTIC WORK

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Abstract
The equation giving the amt. of osmotic work required of the kidney for the formation of urine as a function of urine vol., urine composition, and composition of the glomerular filtrate, is derived. From this it follows that, for fixed rate of excretion of urinary solids, the amt. of work will be the least when the total vol. is so adjusted, that the osmolar conc. of the urine is equal to that of the glomerular fluid. Considering changes in any solid component, any variation which makes the urinary conc. more nearly equal to the glomerular fluid conc. will reduce the osmotic work. Various changes observed in blood and urine in cases of chronic nephritis and certain exptl. conditions are shown to be reasonable on the basis of these considerations.

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