Cerebrovascular Effects of Central Depressants: A Study of Nitrous Oxide, Halothane, Pentobarbital and Ethanol during Normocapnia and Hypercapnia in the Rat
- 1 October 1979
- journal article
- research article
- Published by Wiley in Acta Pharmacologica et Toxicologica
- Vol. 45 (4) , 287-295
- https://doi.org/10.1111/j.1600-0773.1979.tb02395.x
Abstract
The effect of the central depressants nitrous oxide, halothane, pentobarbital and ethanol upon cerebral blood flow (CBF), cerebral oxygen consumption (CMRO2) and cerebral vascular reactivity to carbon dioxide were measured using the rapid and repetitive intraarterial 133Xenon injection technique modified for rat studies. The cerebrovascular resistance (CVR) during normocapnia in the pentobarbital group was significantly higher (P2 and cerebral vascular reactivity. Finally, it is concluded that nitrous oxide anaesthesia (70% N2O: 30% O2) is suitable as a reference situation in rat studies of the effect of pharmocological agents on CBF, CMRO2 and cerebrovascular reactivity.Keywords
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