Immune Response to a Heat-Inactivated Hepatitis B Vaccine in Patients Undergoing Hemodialysis
- 1 February 1985
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 145 (2) , 305-309
- https://doi.org/10.1001/archinte.1985.00360020145023
Abstract
• In a randomized trial, 227 patients undergoing hemodialysis who were seronegative for all markers of hepatitis B virus were Immunized at monthly Intervals with three doses of either 3 μg or 27 μg of heat-Inactivated hepatitis B HB-vaccine (CLB). Five months after the first Injection, 77% of the patients in the 3-μg group and 94% in the 27-μg group manifested antibodies against hepatitis B surface antigen (anti-HBs). At month 12 the proportions of subjects with antl-HBs in the 3-μg and 27-μg groups had dropped to 68% and 87%, respectively. At all times, the differences in the anti-HBs conversion rate between the two treatment groups were significant. These results show that the impaired immune reactivity to hepatitis B vaccines of patients undergoing hemodialysis can be overcome by increasing the dose of the vaccine. (Arch Intern Med1985;145:305-309)This publication has 0 references indexed in Scilit: