Different Aminoglycoside-Resistant Phenotypes in a Rabbit Staphylococcus aureus Endocarditis Infection Model
Open Access
- 1 May 2002
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 46 (5) , 1591-1593
- https://doi.org/10.1128/aac.46.5.1591-1593.2002
Abstract
The impact of different types of enzymatic resistance on the in vivo antibacterial activity of aminoglycosides (amikacin, gentamicin, and netilmicin) was studied in the rabbit endocarditis model with four strains of Staphylococcus aureus. Animals were treated in a manner simulating the administration of a single daily human dose. Amikacin had no effect on the three kanamycin-resistant strains despite apparent susceptibility in the disk diffusion test. Gentamicin appears to be the preferable aminoglycoside for treatment of staphylococcal infections.Keywords
This publication has 21 references indexed in Scilit:
- New guidelines for the antibiotic treatment of streptococcal, enterococcal and staphylococcal endocarditis.Journal of Antimicrobial Chemotherapy, 1998
- A meta-analysis of studies on the safety and efficacy of aminoglycosides given either once daily or as divided dosesJournal of Antimicrobial Chemotherapy, 1996
- Antibiotic Treatment of Adults With Infective Endocarditis Due to Streptococci, Enterococci, Staphylococci, and HACEK MicroorganismsPublished by American Medical Association (AMA) ,1995
- Methicillin-resistant Staphylococcus aureus: A consensus review of the microbiology, pathogenesis, and epidemiology with implications for prevention and managementThe American Journal of Medicine, 1993
- Pharmacokinetic and pharmacodynamic requirements for antibiotic therapy of experimental endocarditisAntimicrobial Agents and Chemotherapy, 1992
- Gene homogeneity for aminoglycoside-modifying enzymes in gram-positive cocciAntimicrobial Agents and Chemotherapy, 1990
- Effect of aminoglycoside concentration on reaction rates of aminoglycoside-modifying enzymesAntimicrobial Agents and Chemotherapy, 1988
- Clinical Response to Aminoglycoside Therapy: Importance of the Ratio of Peak Concentration to Minimal Inhibitory ConcentrationThe Journal of Infectious Diseases, 1987
- Prevalence and mechanisms of aminoglycoside resistance: A ten-year studyThe American Journal of Medicine, 1986
- Purification and characterization of aminoglycoside-modifying enzymes from Staphylococcus aureus and Staphylococcus epidermidisAntimicrobial Agents and Chemotherapy, 1984