The Arabidopsis homolog of trithorax, ATX1, binds phosphatidylinositol 5-phosphate, and the two regulate a common set of target genes
- 11 April 2006
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 103 (15) , 6049-6054
- https://doi.org/10.1073/pnas.0600944103
Abstract
The Arabidopsis homolog of trithorax, ATX1, regulates numerous functions in Arabidopsis beyond the homeotic genes. Here, we identified genome-wide targets of ATX1 and showed that ATX1 is a receptor for a lipid messenger, phosphatidylinositol 5-phosphate, PI5P. PI5P negatively affects ATX1 activity, suggesting a regulatory pathway connecting lipid-signaling with nuclear functions. We propose a model to illustrate how plants may respond to stimuli (external or internal) that elevate cellular PI5P levels by altering expression of ATX1-controlled genes.Keywords
This publication has 38 references indexed in Scilit:
- Linking lipids to chromatinCurrent Opinion in Genetics & Development, 2004
- The PHD Finger of the Chromatin-Associated Protein ING2 Functions as a Nuclear Phosphoinositide ReceptorCell, 2003
- ATX-1, an Arabidopsis Homolog of Trithorax, Activates Flower Homeotic GenesCurrent Biology, 2003
- Polycomblike PHD Fingers Mediate Conserved Interaction with Enhancer of Zeste ProteinJournal of Biological Chemistry, 2001
- Inositol lipids are regulated during cell cycle progression in the nuclei of murine erythroleukaemia cellsBiochemical Journal, 2001
- Structural Mechanism of Endosome Docking by the FYVE DomainScience, 2001
- Biochemical analyses of the AF10 protein: the extended LAP/PHD-finger mediates oligomerisation 1 1Edited by T. RichmondJournal of Molecular Biology, 2000
- The language of covalent histone modificationsNature, 2000
- Crystal structure of the Cys2 activator-binding domain of protein kinase Cδ in complex with phorbol esterPublished by Elsevier ,1995
- Genetic Control of Flower Development by Homeotic Genes in Antirrhinum majusScience, 1990