Fungal products. Part 21. Biosynthesis of the fungal metabolite, wortmannin, from [1,2-13C2]-acetate

Abstract
The 13C-n.m.r, spectrum of wortmannin, enriched with sodium [1,2-13C2]-acetate by cultures of Peniciilium wortmannii, is consistent with the biogenesis of this metabolite via triterpenoid intermediates. Although the overall incorporation of 13C was low, 33C–13C coupling was observed between carbon atoms derived from adjacent acetate units in addition to the expected coupling between carbon atoms in intact acetate units.

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