Comparative intraperitoneal pharmacokinetics of three platinum analogues
- 1 July 1991
- journal article
- research article
- Published by Springer Nature in Cancer Chemotherapy and Pharmacology
- Vol. 28 (4) , 315-317
- https://doi.org/10.1007/bf00685543
Abstract
Summary The pharmakokinetic profiles of intraperitoneally infused platinum analogues were determined in 13 women exhibiting minimal residual disease following surgery and systemic chemotherapy for epithelial ovarian cancer of fallopian tube carcinoma by following the disposition of tracer doses of195mPt radiolabel. Six patients received iproplatin, four were given cisplatin and three received carboplatin. The present data demonstrate no difference in the disposition of total platinum between these three analogues, but differences in the kinetics of free platinum may exist.Keywords
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