Infection and Nutritional Status: II. Effect of Mild Virus Infection Induced by 17-D Yellow Fever Vaccine on Nitrogen Metabolism in Children

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Abstract
Eight boys and one girl, ranging from four to eleven years of age, and from 11.7 to 21.1 kg. in weight, were inoculated with yellow fever vaccine. Two to four three-day periods in which nitrogen balance was determined preceded and followed the vaccination. The basal diet contained 2.5 gm. of protein and 100 calories/kg. of body weight. Body temperature was measured every four hours throughout all periods and no fever developed in any of the children. In eight of the nine children, nitrogen retention decreased significantly although neither absorption nor intake were significantly affected. It is possible that the inoculation did not take in the child who showed no change in nitrogen metabolism. In the eight children showing a response, the drop in nitrogen retention averaged 30 per cent of the nitrogen intake and 35 per cent of the nitrogen absorbed. The decreased retention was due almost entirely to increased nitrogen excretion in the urine

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