The Effect of Estrogen on the Gingiva and Alveolar Bone of Molars in Rats and Mice

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Abstract
The effect of estrogens on the alveolar process, gingival epithelium and epithelial attachment of the molar teeth was studied in 16 newborn rats, 22 newborn mice, and 32 1-yr. old mice. Newborn rats and newborn mice received a total of 0.05-1.30 mg. of alpha-estradiol benzoate or diethyl-stilbestrol over a period of 5-42 days. Old mice were given either a subcut. implant of 2 mg. of crystalline alpha estradiol benzoate or injns. of a total of 1.5-6 mg. of alpha-estradiol benzoate over a max. period of 13 wks. Roentgenologic and histologic investigation revealed that the young rats failed to show any response. In young mice which received more than 0.8 mg. of alpha-estradiol benzoate or diethylstilbestrol, the hemopoietic marrow spaces of the alveolar process were narrowed and contained fibrous tissue. In old mice changes were striking. There was an increased downgrowth of the epithelium of interdental papillae. The epithelial attachment also grew along the root surfaces and interradicular areas. Later, due to its separation from the tooth surfaces, interdental and interradicular pockets developed and the corresponding bony septa showed resorption.