Effect of the lonophore, A23187, on Contraction and Relaxation of Rat Arteries and Veins

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Abstract
The present study describes differences in the effect of the ionophore, A23187 [2-[(3,9,11-trimethyl)8,12-pyrrole carboxymethyl-1,7-dioxaspiro [6.6]undecyl-2-methyl]-5-methyl amino benzoxazole-4-carboxylic acid], on contraction and relaxation in certain rat arteries and veins. A23187 selectively inhibited maximal contraction to receptor agonists such as serotonin and norepinephrine in veins but not arteries. Based on the role of extracellular Ca, the action of A23187 and measurement of total Ca levels, no difference in Ca handling was apparent between the rat jugular and femoral veins. Relaxation of the rat jugular vein to norepinephrine is probably unrelated to any uniqueness in Ca utilization.