The synthesis and antitumor activities of tropolone and 8-hydroxyquinoline derivatives.

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Abstract
The bis-derivatives (4-6) of 8-hydroxyquinoline, which, like tropolones, readily form a chelate, were synthesized and found to be actively antitumorous in tests of survival using P388 mice. 4 was almost as potent as bistropolone (2a).

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