Intracellular pH Regulates the Production of Different Oxygen Metabolites in Neutrophils: Effects of Organic Acids Produced by Anaerobic Bacteria
- 1 February 1991
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Leukocyte Biology
- Vol. 49 (2) , 180-188
- https://doi.org/10.1002/jlb.49.2.180
Abstract
The effects of short chain carboxylic acids (SCCA), namely succinic, butyric, and iso-butyric, on neutrophil metabolic activation were assessed. SCCA induced a significant decrease in O2 - recovery and chemlluminescent response in neutrophils activated with the diacylglycerol analog tetradecanoyl-phorbol-acetate (TPA). SCCA did not alter O2 consumption, H2O2 production, or the calorimetrically determined energy expenditure occurring during the metabolic burst. SCCA also induced a significant acidification of intracellular pH (pHi). These results are consistent with an increased divalent versus univalent O2 reduction performed by the NADPH oxidase at a more acidic intracellular pH.Keywords
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