Mouse models of male infertility
- 1 October 2002
- journal article
- review article
- Published by Springer Nature in Nature Reviews Genetics
- Vol. 3 (10) , 790-801
- https://doi.org/10.1038/nrg911
Abstract
Spermatogenesis is a complex process that involves stem-cell renewal, genome reorganization and genome repackaging, and that culminates in the production of motile gametes. Problems at all stages of spermatogenesis contribute to human infertility, but few of them can be modelled in vitro or in cell culture. Targeted mutagenesis in the mouse provides a powerful method to analyse these steps and has provided new insights into the origins of male infertility.Keywords
This publication has 114 references indexed in Scilit:
- Identification and Sequencing the Juvenile Spermatogonial Depletion Critical Interval on Mouse Chromosome 1 Reveals the Presence of Eight Candidate GenesBiochemical and Biophysical Research Communications, 2001
- Targeted Disruption of the Transition Protein 2 Gene Affects Sperm Chromatin Structure and Reduces Fertility in MiceMolecular and Cellular Biology, 2001
- Inhibins, activins and follistatin: actions on the testisMolecular and Cellular Endocrinology, 2001
- Teratozoospermia in mice lacking the transition protein 2 (Tnp2)Molecular Human Reproduction, 2001
- Transition nuclear proteins during spermiogenesis: Unrepaired DNA breaks not allowedMolecular Reproduction and Development, 2001
- CREM activator and repressor isoforms in human testis: sequence variations and inaccurate splicing during impaired spermatogenesisMolecular Human Reproduction, 2000
- Morphological changes in the vas deferens and expression of the cystic fibrosis transmembrane conductance regulator (CFTR) in control, ?F508 and knock-outCFTR mice during postnatal lifeMolecular Reproduction and Development, 2000
- Y chromosome and male infertilityReviews of Reproduction, 1999
- A severe phenotype in mice with a duplication of exon 3 in the cystic fibrosis locusHuman Molecular Genetics, 1993
- Cystic fibrosis in the mouse by targeted insertional mutagenesisNature, 1992