Diagnosis of Non-Hodgkin??s Lymphoma Intracerebral Mass Lesions Usefulness of Tc-99m Pertechnetate and Ga-67 Citrate Brain Scans

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Abstract
Clinical and diagnostic features of 5 reports of patients with intracerebral, non-Hodgkin''s lymphoma. In 3 patients the brain lesion was the only evidence of lymphoma, while 2 patients also had concomitant systemic involvement. Four patients had diffuse histiocytic lymphoma and 1 had a mixed type of malignant lymphoma. In all patients, 99mTc and 67Ga brain scans disclosed discrete areas of increased radionuclide uptake consistent with a mass. In each case, brain blood perfusion studies were normal and brain computerized tomographic scans and cerebral angiograms produced variable nondiagnostic patterns. Craniotomies in 4 patients provided histologic confirmation of the non-Hodgkin''s lymphoma in the areas of abnormality. The remaining patient had systemic histiocytic lymphoma with concomitant brain lesions that responded to irradiation. The combined use of the above noninvasive modalities in correlation with clinical findings may result in more accurate prebiopsy diagnoses of intracerebral lymphoma.