Muscle Creatine: In Vivo Depletion by Feeding β-Guanidinopropionic Acid

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Abstract
The purpose of this work was to determine the in vivo effect of β-guanidinopropionic acid (β-GPA) on the metabolism of creatine. Diets containing the synthetic creatine analogue, β-GPA, were fed to pregnant female and young male rats.All rats receiving diets containing β-GPA developed the following signs of abnormal creatine metabolism: reduced muscle levels of creatine, reduced urinary excretion of creatinine, and an increase in urinary excretion of creatine.Twelve hours after an injection of creatine-1-14C, rats fed β-GPA had a lower radioactivity level (c.p.m.) in muscle but a higher level in urine than did rats fed the same diet without β-GPA.It is proposed that abnormal creatine metabolism results from an inhibition of creatine entry into muscle from plasma by β-GPA.

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