Influence of Human Cerebrospinal Fluid on Blood Coagulation in Vitro

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Abstract
Introduction SEVERAL YEARS ago an hydrocephalic infant died of sepsis, extensive intravascular thrombosis, and afibrinogenemia following a ventriculoatriostomy. Although it was recognized at that time that this complication was explicable on the basis of infection and shock, the question was posed, did the introduction of cerebrospinal fluid (CSF) into the circulation affect coagulation in vivo and might this become an important factor in limiting the effectiveness of shunt surgery? Since then complications of ventriculoatriostomy have been encountered frequently and local clotting with or without infection has often plagued success. But extensive intravascular clotting has never been encountered subsequently by us in over 65 cases, and has not to our knowledge been reported by others. Nevertheless, this isolated experience prompted us to study the influence of CSF on various in vitro blood clotting systems. The present report is based on these studies. Methods and Materials Plasma (oxalated) and serum samples were

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