Fey receptors in phagocytes

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Abstract
Polymorphonuclear neutrophils, monocytes, and macrophages have numerous important functions in immunity, particularly the ingestion of antibody-coated microorganisms and cells. This review focuses on recent progress in the understanding of the family of receptors for the Fc end of IgG (Fc-γR) on these phagocytes. The control of FcγR expression, the cellular output signals from receptor engagement, and the basis of immediate and downstream signals in phagocyte activation are reviewed. Mice are increasingly being used in transgenic and knockout models of FcγR biology. Relevant differences in the FcγR endowments of mice and humans are detailed.

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