ANTICHOLINESTERASE ACTIVITY OF SOME BUTYROPHENONES

  • 1 January 1978
    • journal article
    • research article
    • Vol. 234  (1) , 58-63
Abstract
The anticholinesterase (antiChE) activity of haloperidol, droperidol and trifluperidol was studied by employing dog plasma as a cholinesterase source and changes in arterial blood pressure, elicited by a mixture of acetylcholine (Ach) and dog plasma with or without those drugs, as an indicator of their antiChE activity. When butyrophenones were present in concentrations of 0.5 up to 5 .times. 10-4 M in plasma containing Ach the hypotensive effect of the latter was preserved. Butyrophenones may exert antiChE activity, which contributes to the understanding of some of the neural effects of these drugs.