Positive Direct Antiglobulin Test in Normal Individuals1

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Abstract
Normal, healthy people (65) with a positive direct antiglobulin test (DAT) were identified in a population of blood donors over a period of 14 yr. Of them, 32 were recalled for detailed study. A strong positive correlation with increasing age was noted, comparable to that seen in hospital patients with a positive DAT. No feature known to cause a positive DAT was identified in the healthy individuals, only 1 of whom went on to develop autoimmune hemolytic anemia.