Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma.
- 1 November 1998
- journal article
- clinical trial
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 16 (11) , 3570-3575
- https://doi.org/10.1200/jco.1998.16.11.3570
Abstract
PURPOSEThe major mechanism of resistance to alkylnitrosourea therapy is the DNA repair protein O6-alkylguanine-DNA alkyltransferase (AGT), which removes chlorethylation or methylation damage from t...Keywords
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