EFFECTS OF NEONATAL THYMECTOMY ON HAEMOLYSIN RESPONSE TO SHEEP ERYTHROCYTES IN SWISS ALBINO MICE - A TIME-COURSE STUDY OF TOTAL 19S AND 7S ANTIBODY

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  • 1 January 1967
    • journal article
    • research article
    • Vol. 12  (5) , 549-+
Abstract
Mice thymectornized inthin 24 hours of birth were immunized by intraperitoneal injection of sheep erythrocytes at 6 weeks of age and again 60 days later. Serum hemolysin activity was measured at various times following antigen injection. The serum hemolysln was fractionated by sucrose gradient centrifugation into 2 classes. A time-course of the antibody response was constructed for total, 19S and 7S hemolysins. Both reduction in circulating antibody activity and delay in reaching maximal levels were observed.