Renal Filtration, Absorption and Catabolism of Human Alpha Interferon
- 1 January 1981
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Interferon Research
- Vol. 1 (3) , 347-352
- https://doi.org/10.1089/jir.1981.1.347
Abstract
The renal handling of human interferon-.alpha. [IFN-.alpha.] has been evaluated in an isolated and perfused rabbit kidney. IFN-.alpha. disappears from plasma with a t1/2 [half-life] of 81 min and the fractional turnover rate is 0.84%/min. About 47 molecules of IFN-.alpha. are filtrated with 100 molecules of creatinine but most of the IFN is absorbed by tubular cells. This is the 1st report showing that human IFN-.alpha. is filtrated by the kidney, is largely absorbed, most probably catabolized within tubular epithelium and excreted in negligible amounts with the urine.This publication has 28 references indexed in Scilit:
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