ACTIVATION OF HEAT LOSS MECHANISMS BY LOCAL HEATING OF THE BRAIN

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Abstract
Local heating of the brain of the cat with low voltage, high frequency current passing between electrodes oriented with the Horsley-Clarke apparatus has demonstrated a reactive region at the ant. end of the brain stem which responds to an elevation of temp. by initiating heat loss activities, with marked acceleration of respiration, panting and the appearance of sweat on the foot pads. The reactive elements seem to be conc. in the preoptic region and ant. part of the hypothalamus, and are continued backward in lesser conc. and apparently to a subsidiary degree of importance, through the diencephalon to the ant. end of the midbrain. The reactive field contains structures which evidently are activated by the rising temp. of the blood, and lead to heat loss activity in the normal animal when overheated.

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