The Effect of Methotrexate on the Development of Synapses in the Neonatal Rat Hippocampus
- 31 October 1989
- journal article
- research article
- Published by Georg Thieme Verlag KG in Neuropediatrics
- Vol. 20 (04) , 196-198
- https://doi.org/10.1055/s-2008-1071291
Abstract
The effects of postnatal methotrexate (MTX) exposure on the development of synapses in the developing rat hippocampus were examined. The density of E-PTA-stained synaptic junctions per unit area was significantly reduced by MTX exposure either during day 1-5 or 6-10 post partum. It was suggested that administering MTX during the critical period affected the development of synapses in the developing rat brain.Keywords
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