Protein phosphorylation in normal and neoplastic development. Cyclic AMP-dependent protein kinase activity in urethane-induced pulmonary tumours
- 15 November 1977
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 168 (2) , 319-321
- https://doi.org/10.1042/bj1680319
Abstract
The cyclic[c]AMP-dependent protein kinase [EC 2.7.1.37] specific activities of cytosol fractions from urethane-induced lung tumors and normal mouse lung were determined. Basal and cAMP-stimulated activities in tumors were 2-fold higher than those of normal lung. Since neonatal and adult lung cytosols have identical kinase activities, the high activity in tumors appears to be a tumor-specific property.This publication has 20 references indexed in Scilit:
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