Comparative Fate of the Geometric Isomers of Phosphamidon in Plants and Animals12

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Abstract
The fates of the cis and trans isomers of phosphamidon in plants and animals were determined by using radiometric and other procedures. The biological half-lives of toxic forms of the 2 isomers were very short in plants and animals and of comparable duration. Although both isomers were converted to similar oxidative and hydrolytic metabolites, the rates of formation were somewhat different; the faster rate of oxidative N-dealkylation of cis phosphamidon in all biological systems was particularly apparent. Not only were the trans isomers of phosphamidon and its N-deethyl derivative substantially more toxic to adult boll weevils Anthonomus grandis Boheman. and house flies, Musca domestica L., than were the cis isomers, but they also were significantly more potent inhibitors of acetyl cholinesterase in the insects. Combinations of sesamex with cis and trails phosphamidon and N-deethyl derivatives caused a substantial increase ill the toxicity of all compounds to boll weevils, particularly the cis isomers.

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