SUPPRESSION OF HUMORAL AND DELAYED-HYPERSENSITIVITY RESPONSES BY DISTINCT T-CELL SUB-POPULATIONS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 121  (2) , 539-542
Abstract
Immunization of mice with a supraoptimal dose of sheep red blood cells (SRBC) results in splenic T [thymus-derived] cell populations capable of specifically suppressing recipients'' plaque-forming cell (PFC) and delayed-type hypersensitivity (DTH) responses to SRBC when tested in an adoptive transfer system. By localization on discontinuous bovine serum albumin (BSA) gradients and relative sensitivity to Cytoxan, two distinct T cell subpopulations suppressing DTH reactivity were identified. One population could not be distinguished from T cells capable of inhibiting direct and indirect PFC responses. Another population appeared quite distinct and capable of inhibiting DTH, but not PFC responses.