Increased NADH-Oxidase–Mediated Superoxide Production in the Early Stages of Atherosclerosis
- 20 April 1999
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 99 (15) , 2027-2033
- https://doi.org/10.1161/01.cir.99.15.2027
Abstract
Background—Angiotensin II activates NAD(P)H-dependent oxidases via AT1-receptor stimulation, the most important vascular source of superoxide (O2·−). The AT1 receptor is upregulated in vitro by low...Keywords
This publication has 18 references indexed in Scilit:
- Quantification of Superoxide Radical Formation in Intact Vascular Tissue Using aCypridinaLuciferin Analog as an Alternative to LucigeninBiochemical and Biophysical Research Communications, 1998
- The Angiotensin-II Receptor Antagonist, Losartan, Inhibits LDL Lipid Peroxidation and Atherosclerosis in Apolipoprotein E-Deficient MiceBiochemical and Biophysical Research Communications, 1997
- Spin Trapping of Superoxide Radicals and Peroxynitrite by 1-Hydroxy-3-carboxy-pyrrolidine and 1-Hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine and the Stability of Corresponding Nitroxyl Radicals Towards Biological ReductantsBiochemical and Biophysical Research Communications, 1997
- Superoxide anion formation from lucigenin: an electron spin resonance spin‐trapping studyFEBS Letters, 1997
- Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug.Journal of Clinical Investigation, 1996
- Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.Journal of Clinical Investigation, 1996
- Angiotensin induction of PAI-1 expression in endothelial cells is mediated by the hexapeptide angiotensin IV.Journal of Clinical Investigation, 1995
- Hypercholesterolemia increases endothelial superoxide anion production.Journal of Clinical Investigation, 1993
- Preservation of Endothelial Function by Ramipril in Rabbits on a Long-Term Atherogenic DietJournal of Cardiovascular Pharmacology, 1991
- Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta.Journal of Clinical Investigation, 1990