IMMUNOREACTIVE SUBSTANCE-P CONTENT IN MEDIAN-EMINENCE AND PITUITARY-GLAND DURING ESTRUS, DIESTRUS AND AFTER ANTERIOR HYPOTHALAMIC DEAFFERENTATION

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 79  (1) , 25-34
Abstract
A relation between the Substance P (SP) content in the median eminence and the pituitary gland in rats and hypothalamic regulation of the estrus cycle was sought. SP content was measured by radioimmunoassay in female rat pituitary and median eminence during estrus, diestrus and after anterior hypothalamic deafferentation. SP content in rat pituitary did not vary significantly among individual groups of animals. The greatest average SP content in rat median eminence was found in diestrus. Both during cyclic and constant estrus resulting from anterior hypothalamic deafferentation SP content in median eminence was lower than in diestrus. This fact indicates the possibility of SP involvement in the control of cyclic LHRH release from the hypothalamus.