OPIATE PEPTIDES CONTROL GROWTH HORMONE THROUGH A CHOLINERGIC MECHANISM IN MAN
- 1 April 1983
- journal article
- research article
- Published by Wiley in Clinical Endocrinology
- Vol. 18 (4) , 401-405
- https://doi.org/10.1111/j.1365-2265.1983.tb00585.x
Abstract
Opiate peptides elevate circulating GH [growth hormone] in man, and data in other animals suggest that acetylcholine may be involved. The long-acting met-enkephalin analog DAMME [D-Ala2-MePhe4-met-enkephalin-(o)-ol] was administered to 6 normal males, and the resulting elevation in GH is blocked by the specific cholinergic antgonist, pirenzipine. It seems likely that a cholinergic mechanism may interact with opiate-induced changes in GH in man.This publication has 12 references indexed in Scilit:
- OPIATES CONTROL ACTH THROUGH A NORADRENERGIC MECHANISMClinical Endocrinology, 1982
- Regulation of Episodic Growth Hormone Secretion by the Central Epinephrine SystemJournal of Clinical Investigation, 1982
- Possible Involvement of γ-Aminobutyric Acid in Growth Hormone Release Induced by a Met5-Enkephalin Analog in Conscious Rats*Endocrinology, 1981
- Changes in pituitary hormone levels induced by met-enkephalin in man—The role of dopamineLife Sciences, 1981
- Endogenous cholinergic modulation of growth-hormone secretion in normal and acromegalic humansMetabolism, 1980
- Growth Hormone-Releasing Effect of an Enkephalin Analog in the Dog: Evidence for Cholinergic Mediation*Endocrinology, 1980
- Pirenzepine distinguishes between different subclasses of muscarinic receptorsNature, 1980
- HORMONAL AND METABOLIC RESPONSES TO AN ENKEPHALIN ANALOGUE IN NORMAL MANThe Lancet, 1978
- Effect of Neurotensin, Substance P and Morphine Sulfate on the Secretion of Prolactin and Growth Hormone in the RatEndocrinology, 1977