Removal of Exogenous Plasma Triglycerides in Forearm Muscle and Subcutaneous Tissue of Hyper‐and Normotriglyceridaemic Men

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Abstract
Absolute arterio-venous removal and fractional removal of blood-born exogenous triglyceride particles [TG] by skeletal and subcutaneous tissues were determined in 8 normotriglyceridemic and 6 hypertriglyceridemic men. Estimations were made by simultaneously sampling blood from catheters inserted into a brachial artery, and in the distal direction, into a superficial and deep vein, draining subcutaneous tissue and skeletal muscle, respectively. During the infusion of the fat emulsion Intralipid for 3 h, steady arterial concentrations of exogenous TG particles were found, indicating 1st order kinetics. In all subjects absolute arterio-venous and fractional removal of triglycerides were about twice as high in skeletal muscle as in subcutaneous tissue. In skeletal muscle the fractional removal and absolute removal were significantly higher in normotriglyceridemic than in hypertriglyceridemic subjects (P < 0.001). No decrease in removal with time was observed, which would have suggested saturation of removal sites. Mean fractional removal in skeletal muscle was significantly correlated with the k2 value determined by an i.v. fat tolerance test before the infusion study ([correlation coefficient] r = 0.61, P < 0.05). In subcutaneous tissue fractional removal was also significantly higher in normotriglyceridemic subjects (P < 0.05). In both skeletal muscle and subcutaneous tissue the removal system may be impaired in hypertriglyceridemic subjects. This finding supports the concept that a decreased elimination capacity in these tissues may partly account for triglyceride elevation in hypertriglyceridemic subjects.