ACUTE THEOPHYLLINE INTOXICATION - BIPHASIC 1ST ORDER ELIMINATION KINETICS IN A CHILD

  • 1 January 1978
    • journal article
    • research article
    • Vol. 41  (6) , 337-339
Abstract
An acute theophylline [an asthma medication] intoxication in a child is reported. It was characterized by 2 distinct first-order elimination processes with t1/2 [half-life] = 12.6 h (ke [elimination rate constant] = 0.057 h-1) and t1/2 = 5.4 h (ke = 0.128 h-1), respectively. The slower process, which was seen at high plasma levels, may represent renal plus saturated hepatic elimination. The later, more rapid process seen at therapeutic plasma levels is consistent with hepatic elimination by biotransformation.

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