VENOUS CONGESTION OF THE EXTREMITIES IN RELATION TO BLOOD VOLUME DETERMINATIONS AND TO MIXING CURVES OF CARBON MONOXIDE AND T-1824 IN NORMAL HUMAN SUBJECTS 1

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Abstract
Venous congestion was produced by pneumatic cuffs surrounding both legs and one arm of each of 3 healthy human subjects. Expts. with prolonged re-breathing of CO showed that 20-28% of the total blood volume was contained in the congested areas at cuff pressures just below diastolic; that this was about twice the blood volume in the same limbs when uncongested; and that CO was distributed uniformly between congested and uncongested parts of the circulation within 20 min. after CO rebreathing was begun. Apparent total blood volume, measured with CO and T-1824, was the same during massive congestion as under resting conditions, when the interval between delivery of the indicator and blood sampling was 20 min. or more. Time-concentration curves of CO and T-1824, made with and without congestion, had slight but consistent differences in contour and showed that sampling periods shorter than 15 min. may cause important errors in blood volume detns. made during venous congestion.

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