Initial photochemotherapy of psoriasis with orally administered 8-methoxypsoralen and longwave ultraviolet light 'PUVA)

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Abstract
Patients with psoriasis [107] underwent initial PUVA therapy. Complete clearance was obtained in 52.3% of the patients, incomplete in 40.2% while 7.5% of the patients did not respond at all. The non-responders to the regular PUVA treatment regime (0.5 mg 8-MOP/kg body wt) were given an increased 8-MOP (8-methoxypsoralen) dose schedule (0.6 mg 8-MOP/kg body wt) and in 90.9% of these patients their lesions cleared after 35 PUVA exposures. A small percentage (9.1%) of the non-responders to the normal dose schedule did not want to continue the increased 8-MOP dose schedule because of persistent nausea. For this reason they were given regular PUVA therapy and they reacted well, but only after 55 exposures. Irrespective of the complete or incomplete clearance of psoriasis the patients remained in remission for a mean period of about 5 1/2 mo. During the remission period the patients were advised to use a tar preparation or topical corticosteroids in the event of minor exacerbations.

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