Lack of an Association of Estrogen Receptor α Gene Polymorphisms and Transcriptional Activity With Alzheimer Disease
Open Access
- 1 February 2000
- journal article
- clinical trial
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 57 (2) , 236-240
- https://doi.org/10.1001/archneur.57.2.236
Abstract
ALZHEIMER disease (AD) is a progressive neurodegenerative disease. The APOE4 genotype is a genetic factor closely related to late-onset AD,1 but the cause of sporadic AD has not been elucidated fully. Other genetic factors may be associated with the development of AD, and further research is essential to resolve important clinical issues and to suggest the site of the therapeutic intervention. Central cholinergic hypofunction is an established component of AD,2,3 and estrogen replacement can significantly enhance basal forebrain cholinergic activity.4Keywords
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