Effects of Isoniazid and Chlortetracycline in the Diet of Young Calves

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Abstract
Forty-four calves were randomized into a control and 3 experiment groups, one of which (group 4) was fed both isoniazid and chlortetracycline whereas, one of the others (group 2) received chlortetracycline and the other (group 3) isoniazid. All calves received pure colostrum through 4 days, a mixture of colostrum and skimmilk through 21 days and skimmilk for the duration of the 60 day period. Hay and concentrates were available free choice. All calves were healthy and the controls gained 53.1 pounds; group 2, 58.6; group 3, 56.4. These differences were not significant. Group 4 gained 62.6 pounds, a difference which was significantly different from the controls at P = 0.05. The effect appeared to be additive rather than synergistic. Feed consumption, general health and changes in height at withers did not vary significantly.

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