Homocysteine accelerates endothelial cell senescence
Open Access
- 13 March 2000
- journal article
- Published by Wiley in FEBS Letters
- Vol. 470 (1) , 20-24
- https://doi.org/10.1016/s0014-5793(00)01278-3
Abstract
In this study we demonstrate that exposure of cultured endothelial cells to homocysteine significantly accelerates the rate of endothelial senescence. Examination of telomere length demonstrates that...Keywords
This publication has 20 references indexed in Scilit:
- Ras Proteins Induce Senescence by Altering the Intracellular Levels of Reactive Oxygen SpeciesJournal of Biological Chemistry, 1999
- Can ends justify the means?: Telomeres and the mechanisms of replicative senescence and immortalization in mammalian cellsProceedings of the National Academy of Sciences, 1998
- Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibitionOncogene, 1997
- A model for p53-induced apoptosisNature, 1997
- Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53Proceedings of the National Academy of Sciences, 1997
- Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4aCell, 1997
- Reactive oxygen species are downstream mediators of p53-dependent apoptosis.Proceedings of the National Academy of Sciences, 1996
- Oxidative Stress, Caloric Restriction, and AgingScience, 1996
- A biomarker that identifies senescent human cells in culture and in aging skin in vivo.Proceedings of the National Academy of Sciences, 1995
- Aging: A Theory Based on Free Radical and Radiation ChemistryJournal of Gerontology, 1956