HYPOMELANOSIS OF ITO

  • 1 January 1977
    • journal article
    • research article
    • Vol. 57  (3) , 261-264
Abstract
Hypomelanosis of Ito appears to be a disorder of hypopigmentation. Findings from histochemical and EM studies indicate that pigment cells from the hypopigmented areas have short dendrites and synthesize less than normal amounts of melanin. The syndrome may have 2 forms; a cutaneous and neurocutaneous variety. In the more severe neurocutaneous variety, the phenotypic pigmentary abnormalities probably reflect a biochemical defect in all tissues derived from the neuro-ectodermal anlage.

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