Chlorphenesin: A New Inhibitor of IgE-Mediated Histamine Release

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Abstract
Several drugs have recently been shown to be active in inhibiting the antigenically induced in vitro release of compounds thought to be involved in anaphylactic reactions. These compounds offer interesting tools with which to study the mechanism of the reactions of immediate hypersensitivity as well as having the potential for therapeutic use in man. Of the drugs already in use in man diethylcarbamazine (Hetrazan), an antifilarial agent, inhibits the release of the slow reacting substance of anaphylaxis (SRS-A) from rat peritoneal leukocytes (1) while disodium chromoglycate (Intal) inhibits the release of histamine from rat mast cells in vivo (2). The latter, however, does not inhibit in vitro histamine release from human leukocytes (L. M. Lichtenstein, unpublished). Both of these drugs are currently being studied for their usefulness in the treatment of human asthma (3, 4). Recently, drugs of the catecholamine and methylxanthine series were shown to inhibit the release of histamine from human leukocytes: evidence was presented to suggest that they operated through the cyclic 3′5′ AMP system (5, 6).

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