STUDIES OF ANTIGEN IN ACUTE AND CHRONIC HEPATITIS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 71  (2) , 208-209
Abstract
Sera from well individuals, including controls and asymptomatic HBsAg [hepatitis B surface antigen] carriers, post-transfusion hepatitis cases, and chronic active liver disease patients were examined for the presence of e antigen and e antibody by rheophoresis. The data confirm the specific association between the e determinant and hepatitis B infections and indicate that e antigen is closely associated with evidence of chronic hepatic dysfunction, in contrast to the association of e antibody with hepatic normalcy in HBsAg carriers. These correlations are not absolute and it should not be inferred that all e antigen-positive individuals will develop chronic hepatitis nor, conversely, that presence of e antibody invariably protects against the development of chronic hepatitis.

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