Pathologic Physiology of Mammalian Blood Platelet Utilizing P32 Tagged Rabbit Platelets.

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Abstract
Purified unagglutinated rabbit platelet suspensions do incorporate radioactive P readily. After 3-hours incubation the radioactivity is in the acid soluble compartment, primarily, and can be washed out. After 14-hours incubation, the radioactivity is in the organic P compartment and cannot be extracted by washing. These platelets, transfused into the donor rabbit, are removed rapidly from the peripheral blood and the radioactivity can be recovered in organs of the reticulo-entiothelial system. It is probable that the procedure to which these platelets are exposed, damages them, as suggested by increased endogenous respiration and failure to cause contraction of a clot prepared from platelet free plasma. However they cause retraction of a clot prepared from purified fibrinogen and restore the abnormal serum prothrombin time of platelet free plasma to normal.

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