National Use of Postmenopausal Hormone Therapy
Top Cited Papers
Open Access
- 7 January 2004
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 291 (1) , 47-53
- https://doi.org/10.1001/jama.291.1.47
Abstract
Patterns of hormone therapy use among postmenopausal women in the United States ideally should reflect known risks and benefits. However, definitive information on these risks and benefits was lacking until recently. The Heart and Estrogen/Progestin Replacement Study (HERS)1 and HERS follow-up (HERS II)2 concluded that postmenopausal hormone therapy with combination oral estrogen/progestin offered no cardiovascular disease benefit among women with established disease. The estrogen plus progestin trial of the Women's Health Initiative (WHI)3 demonstrated that hormone therapy with an estrogen/progestin combination caused increased risk of breast cancer and cardiovascular disease in postmenopausal women. These findings from randomized trials contrast with prior observational studies that suggested cardiovascular benefits.4-6 Based on the quality of recent data, new guidelines recommend against routine hormone therapy use for chronic conditions,7 and current users have been advised to taper doses toward discontinuation.8,9Keywords
This publication has 21 references indexed in Scilit:
- Rethinking Postmenopausal Hormone TherapyNew England Journal of Medicine, 2003
- Assessing Benefits and Harms of Hormone Replacement TherapyJAMA, 2002
- Cardiovascular Disease Outcomes During 6.8 Years of Hormone TherapyJAMA, 2002
- A Prospective, Observational Study of Postmenopausal Hormone Therapy and Primary Prevention of Cardiovascular DiseaseAnnals of Internal Medicine, 2000
- Use of menopausal estrogens and medroxyprogesterone in the United States, 1982–1992Published by Wolters Kluwer Health ,2000
- Use of Hormone Replacement Therapy by Postmenopausal Women in the United StatesAnnals of Internal Medicine, 1999
- Recent Patterns of Hormone Replacement Therapy Use in a Large Managed Care OrganizationJournal of Women's Health, 1998
- Randomized Trial of Estrogen Plus Progestin for Secondary Prevention of Coronary Heart Disease in Postmenopausal WomenJAMA, 1998
- HORMONE REPLACEMENT THERAPY, HEART DISEASE, AND OTHER CONSIDERATIONSAnnual Review of Public Health, 1998
- Prescribing of noncontraceptive estrogens and progestins in the United States, 1974-86.American Journal of Public Health, 1988