Transformation of morphological, functional and metabolic properties of fast-twitch muscle as induced by long-term electrical stimulation
- 1 March 1977
- journal article
- Published by Springer Nature in Basic Research in Cardiology
- Vol. 72 (2-3) , 247-253
- https://doi.org/10.1007/bf01906369
Abstract
Transformation of structural, functional, metabolic and molecular characteristics is induced by stimulating fast-twitch muscles with the frequency pattern of a motoneuron normally innervating a slow-twitch muscle. These changes correspond to a transition of a “fast-white” into a “slow-red” muscle. Intermittent stimulation (8 h/d) does not affect the system but causes alterations of the sarcoplasmic reticulum which lead to changes in time to peak and half relaxation time. Continuous stimulation (24 h/d) induces a transformation of the muscle also at the level of the myosin system. Dauerstimulation schneller Muskeln mit dem Frequenzmuster langsamer Motoneurone induziert in schnellen Kaninchenmuskeln eine Transformation morphologischer, funktioneller, metabolischer und molekularer Merkmale. Diese Veränderungen entsprechen der Umwandlung eines “schnellen/weißen” in einen “langsamen/roten” Muskel. Intermittierende (8 Std/Tag) Stimulation bewirkt keine Umwandlung des Myosins, induziert aber eine solche des sarkoplasmatischen Retikulums. Kontinuierliche (24 Std/Tag) Stimulation bewirkt eine Transformation des Muskels, die auch eine Umwandlung des Myosins einschließt.Keywords
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