Efficient Neuronal Gene Transfer with AAV8 Leads to Neurotoxic Levels of Tau or Green Fluorescent Proteins
Open Access
- 1 March 2006
- journal article
- research article
- Published by Elsevier in Molecular Therapy
- Vol. 13 (3) , 517-527
- https://doi.org/10.1016/j.ymthe.2005.10.008
Abstract
No abstract availableKeywords
This publication has 33 references indexed in Scilit:
- Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the ratNeurobiology of Disease, 2005
- Unrestricted Hepatocyte Transduction with Adeno-Associated Virus Serotype 8 Vectors in MiceJournal of Virology, 2005
- PKC modulation of GABAA receptor endocytosis and function is inhibited by mutation of a dileucine motif within the receptor β2 subunitNeuropharmacology, 2004
- Neuronal co-expression of EGFP and β-galactosidase in mice causes neuropathology and premature deathNeurobiology of Disease, 2004
- Recombinant AAV Viral Vectors Pseudotyped with Viral Capsids from Serotypes 1, 2, and 5 Display Differential Efficiency and Cell Tropism after Delivery to Different Regions of the Central Nervous SystemMolecular Therapy, 2004
- Transduction Profiles of Recombinant Adeno-Associated Virus Vectors Derived from Serotypes 2 and 5 in the Nigrostriatal System of RatsJournal of Virology, 2004
- Rapid Neurofibrillary Tangle Formation after Localized Gene Transfer of Mutated TauThe American Journal of Pathology, 2004
- An R5L τ mutation in a subject with a progressive supranuclear palsy phenotypeAnnals of Neurology, 2002
- Novel Tools for Production and Purification of Recombinant Adenoassociated Virus VectorsHuman Gene Therapy, 1998
- Neuron-Specific Transduction in the Rat Septohippocampal or Nigrostriatal Pathway by Recombinant Adeno-associated Virus VectorsExperimental Neurology, 1998