Effects on tissue and electrolytes of a mineralocorticoid blocker during DOCA-induced potassium depletion

1 February 1976

journal article
Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology

Vol. 54 (1) , 59-65
https://doi.org/10.1139/y76-009

Abstract

Chronic experiments were carried out on three groups of rats to evaluate tissue and electrolyte effects of a mineralocorticoid blocker canrenoate potassium (SC-14266) during DOCA-induced hypokalemic metabolic alkalosis. Group I animals received DOCA alone, group II received DOCA plus canrenoate, while group III received canrenoate alone. The daily dose ratio (per kilogram of body weight) was 180 mg canrenoate – 0.45 mg DOCA. All animals ate a synthetic diet and drank 0.15 N NaHCO₃ Group II animals demonstrated a lesser degree of metabolic alkalosis and a higher muscle potassium content when compared with group I rats. The most conspicuous histological abnormality was myocardial necrosis, the degree and extent of which was impressively reduced by the blocking agent.

Keywords

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