MITOTIC RATIO AND COLCHICINE SENSITIVITY OF THE STOMACH EPITHELIUM OF THE WHITE RAT

Abstract
In the epithelium of the fore-stomach and glandular stomach of the white rat mitoses were found in 15 different age groups, from newborn to 2-year-old. The mitotic ratio in adult animals seemed to decrease with age. The capacity of the cell for mitosis showed a tendency towards regional concentration. It was greatest in the fore-stomach at the junction with the glandular stomach, and in the glandular stomach it was greatest in the pyloric region (in the mucous cells). There was no certain proof of mitosis in chief cells, parietal cells or cells of the superficial epithelium. The squamous epithelial cells in the glandular stomach showed great colchicine sensitivity both in 3-week-old and 1-year-old rats.