Cytotoxic Action of Antisera to Cell Components of Normal and Leukemic Mouse Spleens.

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Abstract
Antisera to cell components (mitochondria, P1, P2, nuclei) from normal and leukemic mouse spleens were cytotoxic when incubated with 100,000 leukemic cells prior to inoculation of mice. The leukemic antisera were relatively more cytotoxic than the normal. The antimitochondria sera exhibited the highest "titers" but the least difference between the leukemic and normal. The most significant differences occurred between the P1 sera with the leukemic antisera showing 8 times the activity of the normal. There was also demonstrated a marked difference in favor of the leukemic antinuclei-serum. A very slight immunity was demonstrated in mice receiving the combination of leukemic cells and leukemic antisera.
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