PROSTAGLANDINS, KININ AND INFLAMMATION IN THE RAT
Open Access
- 1 February 1974
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 50 (2) , 231-235
- https://doi.org/10.1111/j.1476-5381.1974.tb08566.x
Abstract
Prostaglandin E1 and bradykinin exert synergistic effects on vascular permeability in rat skin and in rat paws. Prostaglandin E2 is inactive in this respect. Prostaglandin F2α reduces the bradykinin response in rat skin but not in rat paws. It also markedly reduces the response of the skin to dextran, 5‐hydroxytryptamine and histamine. Prostaglandin E1 and dextran exert synergistic effects in rat skin when threshold doses of each agent are used. Rats genetically resistant to dextran fail to respond to intradermal dextran in the presence of prostaglandin E1.Keywords
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