Spectrophotometry Determination of Famotidine by Charge Transfer Complexation

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Abstract
Three rapid and simple spectrophotometric methods are described for the determination of famotidine. The methods are based on charge transfer complexation of the drug with reagents viz. chloranil, dichloro dicyano benzoquinone and dichloronitrophenol in methanol to give intensely coloured products. The absorbance was measured at the wavelengths of maximum absorption viz. 458, 460 and 425 nm respectively. The effect of several variables on colour development was studied. The mole ratio of the reactants in each case has been established. The proposed methods have been applied successfully for the analysis of famotidine in raw materials and also in tablets.