THE METABOLISM OF TUMORS IN THE BODY

Open Access
Publisher Website
Google Scholar
Abstract
Normal tissues derived energy by respiration (oxidation) only, tumors by respiration and by lactic fermentation of glucose. In vitro, tumor cells survived absence of O or glucose many hrs., but died quickly in deficiency of both. They used several times more glucose than normal tissues, mostly by fermentation. They consumed nearly all the O in their blood supply. Relatively their supply of glucose was moderate, of O very poor. Reducing blood glucose by insulin checked growth but did not kill tumor cells. Reducing blood O by low concentration in inspired air quickly killed most cells of a tumor.

This publication has 0 references indexed in Scilit: